1qx7

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<StructureSection load='1qx7' size='340' side='right'caption='[[1qx7]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
<StructureSection load='1qx7' size='340' side='right'caption='[[1qx7]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1qx7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QX7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1QX7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1qx7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QX7 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.09&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g4y|1g4y]], [[1qx5|1qx5]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CALM1, CAM1, CALM, CAM, CALM2, CAM2, CAMB, CALM3, CAM3, CAMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), KCNN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qx7 OCA], [https://pdbe.org/1qx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qx7 RCSB], [https://www.ebi.ac.uk/pdbsum/1qx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qx7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1qx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qx7 OCA], [http://pdbe.org/1qx7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qx7 RCSB], [http://www.ebi.ac.uk/pdbsum/1qx7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qx7 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT]] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
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[https://www.uniprot.org/uniprot/CALM1_RAT CALM1_RAT] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.[UniProtKB:P62158]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Crum, M]]
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[[Category: Rattus norvegicus]]
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[[Category: Miller, M C]]
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[[Category: Crum M]]
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[[Category: Schumacher, M A]]
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[[Category: Miller MC]]
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[[Category: Apocalmodulin]]
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[[Category: Schumacher MA]]
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[[Category: Ca2+-activated gating]]
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[[Category: Cambd]]
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[[Category: Functioanl bipartism]]
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[[Category: Gating domain]]
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[[Category: Signaling protein]]
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[[Category: Sk channel]]
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[[Category: Small conductance ca2+ activated k+ channel]]
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Revision as of 05:57, 23 August 2023

Crystal structure of apoCaM bound to the gating domain of small conductance Ca2+-activated potassium channel

PDB ID 1qx7

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