1s0u

<table><tr><td colspan='2'>[[1s0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S0U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1S0U FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EIF2G, MJ1261 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 ATCC 43067])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1s0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s0u OCA], [http://pdbe.org/1s0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s0u RCSB], [http://www.ebi.ac.uk/pdbsum/1s0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s0u ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/IF2G_METJA IF2G_METJA]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

The x-ray structure of the gamma-subunit of the heterotrimeric translation initiation factor eIF2 has been determined to 2.4-A resolution. eIF2 is a GTPase that delivers the initiator Met-tRNA to the P site on the small ribosomal subunit during a rate-limiting initiation step in translation. The structure of eIF2gamma closely resembles that of EF1A.GTP, consisting of an N-terminal G domain followed by two beta-barrels arranged in a closed configuration with domain II packed against the G domain in the vicinity of the Switch regions. The G domain of eIF2gamma has an unusual zinc ribbon motif, not previously found in other GTPases. Structure-based site-directed mutagenesis was used to identify two adjacent features on the surface of eIF2gamma that bind the alpha-subunit and Met-tRNA(i)(Met), respectively. These structural, biochemical, and genetic results provide new insights into eIF2 ternary complex assembly.

X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding.,Roll-Mecak A, Alone P, Cao C, Dever TE, Burley SK J Biol Chem. 2004 Mar 12;279(11):10634-42. Epub 2003 Dec 19. PMID:14688270<ref>PMID:14688270</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 1s0u" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Atcc 43067]]

[[Category: Alone, P]]

[[Category: Burley, S K]]

[[Category: Cao, C]]

[[Category: Dever, T E]]

[[Category: Roll-Mecak, A]]

[[Category: Trna]]