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1s8n

From Proteopedia

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Current revision

Crystal structure of Rv1626 from Mycobacterium tuberculosis

Structural highlights

1s8n is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.482Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

PDTAR_MYCTU Member of the two-component regulatory system pdtaR/pdtaS.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

We describe the crystal structure of Rv1626 from Mycobacterium tuberculosis at 1.48 A resolution and the corresponding solution structure determined from small angle X-ray scattering. The N-terminal domain shows structural homology to the receiver domains found in bacterial two-component systems. The C-terminal domain has high structural homology to a recently discovered RNA binding domain involved in transcriptional antitermination. The molecule in solution was found to be monomeric as it is in the crystal, but in solution it undergoes a conformational change that is triggered by changes in ionic strength. This is the first structure that links the phosphorylation cascade of the two-component systems with the antitermination event in the transcriptional machinery. Rv1626 belongs to a family of proteins, which we propose calling phosphorylation-dependent transcriptional antitermination regulators, so far only found in bacteria, and includes NasT, a protein from the assimilatory nitrate/nitrite reductase operon of Azetobacter vinelandii.

The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis.,Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA Structure. 2004 Sep;12(9):1595-605. PMID:15341725^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Morth JP, Gosmann S, Nowak E, Tucker PA. A novel two-component system found in Mycobacterium tuberculosis. FEBS Lett. 2005 Aug 1;579(19):4145-8. PMID:16026786 doi:http://dx.doi.org/10.1016/j.febslet.2005.06.043
↑ Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA. The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis. Structure. 2004 Sep;12(9):1595-605. PMID:15341725 doi:10.1016/j.str.2004.06.018

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s8n"

@@ Line 3: / Line 3: @@
 <StructureSection load='1s8n' size='340' side='right'caption='[[1s8n]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1s8n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S8N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1S8N FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1s8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S8N FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.482&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rv1626 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1s8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s8n OCA], [http://pdbe.org/1s8n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s8n RCSB], [http://www.ebi.ac.uk/pdbsum/1s8n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s8n ProSAT], [http://www.topsan.org/Proteins/XMTB/1s8n TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s8n OCA], [https://pdbe.org/1s8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s8n RCSB], [https://www.ebi.ac.uk/pdbsum/1s8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s8n ProSAT], [https://www.topsan.org/Proteins/XMTB/1s8n TOPSAN]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PDTAR_MYCTU PDTAR_MYCTU]] Member of the two-component regulatory system pdtaR/pdtaS.<ref>PMID:16026786</ref>
+[https://www.uniprot.org/uniprot/PDTAR_MYCTU PDTAR_MYCTU] Member of the two-component regulatory system pdtaR/pdtaS.<ref>PMID:16026786</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 34: / Line 34: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Myctu]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
-[[Category: Feng, V]]
+[[Category: Feng V]]
-[[Category: Morth, J P]]
+[[Category: Morth JP]]
-[[Category: Perry, L J]]
+[[Category: Perry LJ]]
-[[Category: Svergun, D I]]
+[[Category: Svergun DI]]
-[[Category: Structural genomic]]
+[[Category: Tucker PA]]
-[[Category: Tucker, P A]]
-[[Category: PSI, Protein structure initiative]]
-[[Category: Rv1626]]
-[[Category: Tbsgc]]
-[[Category: Transcriptional antiterminator]]
-[[Category: Two component system]]
-[[Category: Unknown function]]

1s8n

From Proteopedia

Current revision

Crystal structure of Rv1626 from Mycobacterium tuberculosis

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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