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6ys9

From Proteopedia

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Current revision (07:40, 1 May 2024) (edit) (undo)
 
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<StructureSection load='6ys9' size='340' side='right'caption='[[6ys9]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
<StructureSection load='6ys9' size='340' side='right'caption='[[6ys9]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ys9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Theeb Theeb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YS9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YS9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ys9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermosynechococcus_vestitus_BP-1 Thermosynechococcus vestitus BP-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YS9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">chlH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=197221 THEEB])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ys9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ys9 OCA], [http://pdbe.org/6ys9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ys9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ys9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ys9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ys9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ys9 OCA], [https://pdbe.org/6ys9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ys9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ys9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ys9 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8DM52_THEVB Q8DM52_THEVB]
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The insertion of magnesium into protoporphyrin initiates the biosynthesis of chlorophyll, the pigment that underpins photosynthesis. This reaction, catalysed by the magnesium chelatase complex, couples ATP hydrolysis by a ChlID motor complex to chelation within the ChlH subunit. We probed the structure and catalytic function of ChlH using a combination of X-ray crystallography, computational modelling, mutagenesis and enzymology. Two linked domains of ChlH in an initially open conformation of ChlH bind protoporphyrin IX, and the rearrangement of several loops envelops this substrate, forming an active site cavity. This induced fit brings an essential glutamate (E660), proposed to be the key catalytic residue for magnesium insertion, into proximity with the porphyrin. A buried solvent channel adjacent to E660 connects the exterior bulk solvent to the active site, forming a possible conduit for the delivery of magnesium or abstraction of protons.
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The active site of magnesium chelatase.,Adams NBP, Bisson C, Brindley AA, Farmer DA, Davison PA, Reid JD, Hunter CN Nat Plants. 2020 Nov 30. pii: 10.1038/s41477-020-00806-9. doi:, 10.1038/s41477-020-00806-9. PMID:33257858<ref>PMID:33257858</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6ys9" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Theeb]]
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[[Category: Thermosynechococcus vestitus BP-1]]
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[[Category: Bisson, C]]
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[[Category: Bisson C]]
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[[Category: Hunter, C N]]
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[[Category: Hunter CN]]
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[[Category: Bacteriochlorophyll]]
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[[Category: Chlorophyll]]
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[[Category: Magnesium chelatase]]
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[[Category: Photosynthesis]]
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Current revision

T_926 truncate of ChlH from Thermosynechococcus elongatus at 1.64 A resolution

PDB ID 6ys9

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