1sse
From Proteopedia
(Difference between revisions)
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<StructureSection load='1sse' size='340' side='right'caption='[[1sse]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='1sse' size='340' side='right'caption='[[1sse]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1sse]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1sse]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SSE FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YAP1, SNQ3, PAR1, PDR4, YML007W, YM9571.12 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YAP1, SNQ3, PAR1, PDR4, YML007W, YM9571.12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sse OCA], [https://pdbe.org/1sse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sse RCSB], [https://www.ebi.ac.uk/pdbsum/1sse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sse ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/YAP1_YEAST YAP1_YEAST]] Transcription activator involved in oxidative stress response and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes and components of the cellular thiol-reducing pathways, including the thioredoxin system (TRX2, TRR1), the glutaredoxin system (GSH1, GLR1), superoxide dismutase (SOD1, SOD2), glutathione peroxidase (GPX2), and thiol-specific peroxidases (TSA1, AHP1). The induction of some of these genes requires the cooperative action of both, YAP1 and SKN7. YAP1 preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of YAP1 is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Oxidative stress (as well as carbon stress, but not increased temperature, acidic pH, or ionic stress) induces nuclear accumulation and as a result YAP1 transcriptional activity. Nuclear export is restored when disulfide bonds are reduced by thioredoxin (TRX2), whose expression is controlled by YAP1, providing a mechanism for negative autoregulation. When overexpressed, YAP1 confers pleiotropic drug-resistance and increases cellular tolerance to cadmium, iron chelators and zinc.<ref>PMID:8182076</ref> <ref>PMID:9372930</ref> <ref>PMID:9857197</ref> <ref>PMID:9469820</ref> <ref>PMID:10347154</ref> <ref>PMID:11013218</ref> <ref>PMID:11274141</ref> <ref>PMID:11509657</ref> <ref>PMID:12437921</ref> <ref>PMID:12582119</ref> <ref>PMID:14556629</ref> <ref>PMID:14556853</ref> <ref>PMID:12743123</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 06:37, 2 March 2022
Solution structure of the oxidized form of the Yap1 redox domain
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