1ddf

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[[Image:1ddf.gif|left|200px]]
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{{STRUCTURE_1ddf| PDB=1ddf | SCENE= }}
{{STRUCTURE_1ddf| PDB=1ddf | SCENE= }}
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'''FAS DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE'''
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===FAS DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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Programmed cell death (apoptosis) mediated by the cytokine receptor Fas is critical for the removal of autoreactive T cells, the mechanism of immune privilege, and for maintenance of immune-system homeostasis. Signalling of programmed cell death involves the self-association of a conserved cytoplasmic region of Fas called the death domain and interaction with another death-domain-containing protein, FADD (also known as MORT1). Although death domains are found in several proteins, their three-dimensional structure and the manner in which they interact is unknown. Here we describe the solution structure of the Fas death domain, as determined by NMR spectroscopy. The structure consists of six antiparallel, amphipathic alpha-helices arranged in a novel fold. From the structure and from site-directed mutagenesis, we have identified the region of the death domain involved in self-association and binding to the downstream signalling partner FADD.
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(as it appears on PubMed at http://www.pubmed.gov), where 8967952 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8967952}}
==About this Structure==
==About this Structure==
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1DDF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDF OCA].
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1DDF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDF OCA].
==Reference==
==Reference==
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[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:43:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:51:28 2008''

Revision as of 19:51, 30 June 2008

Image:1ddf.png

Template:STRUCTURE 1ddf

FAS DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 8967952

About this Structure

1DDF is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain., Huang B, Eberstadt M, Olejniczak ET, Meadows RP, Fesik SW, Nature. 1996 Dec 19-26;384(6610):638-41. PMID:8967952

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