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1t3j

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<StructureSection load='1t3j' size='340' side='right'caption='[[1t3j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1t3j' size='340' side='right'caption='[[1t3j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1t3j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1T3J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1t3j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3J FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MFN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MFN1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1t3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3j OCA], [http://pdbe.org/1t3j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t3j RCSB], [http://www.ebi.ac.uk/pdbsum/1t3j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3j ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3j OCA], [https://pdbe.org/1t3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3j RCSB], [https://www.ebi.ac.uk/pdbsum/1t3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MFN1_MOUSE MFN1_MOUSE]] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:12527753</ref> <ref>PMID:15297672</ref>
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[[https://www.uniprot.org/uniprot/MFN1_MOUSE MFN1_MOUSE]] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:12527753</ref> <ref>PMID:15297672</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 15:38, 27 October 2021

Mitofusin domain HR2 V686M/I708M mutant

PDB ID 1t3j

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