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1dec

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{{STRUCTURE_1dec| PDB=1dec | SCENE= }}
{{STRUCTURE_1dec| PDB=1dec | SCENE= }}
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'''STRUCTURE OF THE RGD PROTEIN DECORSIN: CONSERVED MOTIF AND DISTINCT FUNCTION IN LEECH PROTEINS THAT AFFECT BLOOD CLOTTING'''
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===STRUCTURE OF THE RGD PROTEIN DECORSIN: CONSERVED MOTIF AND DISTINCT FUNCTION IN LEECH PROTEINS THAT AFFECT BLOOD CLOTTING===
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==Overview==
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The structure of the leech protein decorsin, a potent 39-residue antagonist of glycoprotein IIb-IIIa and inhibitor of platelet aggregation, was determined by nuclear magnetic resonance. In contrast to other disintegrins, the Arg-Gly-Asp (RGD)-containing region of decorsin is well defined. The three-dimensional structure of decorsin is similar to that of hirudin, an anticoagulant leech protein that potently inhibits thrombin. Amino acid sequence comparisons suggest that ornatin, another glycoprotein IIb-IIIa antagonist, and antistasin, a potent Factor Xa inhibitor and anticoagulant found in leeches, share the same structural motif. Although decorsin, hirudin, and antistasin all affect the blood clotting process and appear similar in structure, their mechanisms of action and epitopes important for binding to their respective targets are distinct.
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{{ABSTRACT_PUBMED_8009227}}
==About this Structure==
==About this Structure==
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1DEC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Macrobdella_decora Macrobdella decora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEC OCA].
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1DEC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Macrobdella_decora Macrobdella decora]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEC OCA].
==Reference==
==Reference==
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[[Category: Wagner, G.]]
[[Category: Wagner, G.]]
[[Category: Blood coagulation]]
[[Category: Blood coagulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:45:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:53:55 2008''

Revision as of 19:53, 30 June 2008

Image:1dec.png

Template:STRUCTURE 1dec

STRUCTURE OF THE RGD PROTEIN DECORSIN: CONSERVED MOTIF AND DISTINCT FUNCTION IN LEECH PROTEINS THAT AFFECT BLOOD CLOTTING

Template:ABSTRACT PUBMED 8009227

About this Structure

1DEC is a Single protein structure of sequence from Macrobdella decora. Full experimental information is available from OCA.

Reference

Structure of the RGD protein decorsin: conserved motif and distinct function in leech proteins that affect blood clotting., Krezel AM, Wagner G, Seymour-Ulmer J, Lazarus RA, Science. 1994 Jun 24;264(5167):1944-7. PMID:8009227

Page seeded by OCA on Mon Jun 30 22:53:55 2008

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