6pgw
From Proteopedia
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==Crystal structure of zebrafish Protocadherin-19 EC3-6== | ==Crystal structure of zebrafish Protocadherin-19 EC3-6== | ||
| - | <StructureSection load='6pgw' size='340' side='right'caption='[[6pgw]]' scene=''> | + | <StructureSection load='6pgw' size='340' side='right'caption='[[6pgw]], [[Resolution|resolution]] 3.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PGW OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6pgw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PGW FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pcdh19, wu:fc83e05 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pgw OCA], [https://pdbe.org/6pgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pgw RCSB], [https://www.ebi.ac.uk/pdbsum/6pgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pgw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cadherin superfamily members play a critical role in differential adhesion during neurodevelopment, and their disruption has been linked to several neurodevelopmental disorders. Mutations in protocadherin-19 (PCDH19), a member of the delta-protocadherin subfamily of cadherins, cause a unique form of epilepsy called PCDH19 clustering epilepsy. While PCDH19 and other non-clustered delta-protocadherins form multimers with other members of the cadherin superfamily to alter adhesiveness, the specific protein surfaces responsible for these interactions are unknown. Only portions of the PCDH19 extracellular domain structure had been solved previously. Here, we present a structure of the missing segment from zebrafish Protocadherin-19 (Pcdh19) and create a complete ectodomain model. This model shows the structural environment for 97% of disease-causing missense mutations and reveals two potential surfaces for intermolecular interactions that could modify Pcdh19's adhesive strength and specificity. | ||
| + | |||
| + | A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites.,Hudson JD, Tamilselvan E, Sotomayor M, Cooper SR Structure. 2021 Oct 7;29(10):1128-1143.e4. doi: 10.1016/j.str.2021.07.006. Epub, 2021 Sep 13. PMID:34520737<ref>PMID:34520737</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6pgw" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Cadherin 3D structures|Cadherin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Brachidanio rerio]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cooper | + | [[Category: Cooper, S R]] |
| - | [[Category: Hudson | + | [[Category: Hudson, J D]] |
| - | [[Category: Sotomayor M]] | + | [[Category: Sotomayor, M]] |
| + | [[Category: Calcium-binding]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Epilepsy]] | ||
| + | [[Category: Pcdh19]] | ||
| + | [[Category: Protocadherin]] | ||
Revision as of 06:24, 1 December 2021
Crystal structure of zebrafish Protocadherin-19 EC3-6
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