6lk7

<table><tr><td colspan='2'>[[6lk7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp._os17 Pseudomonas sp. os17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LK7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LK7 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PMI18_04289, POS17_1348 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1500686 Pseudomonas sp. Os17])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lk7 OCA], [http://pdbe.org/6lk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lk7 RCSB], [http://www.ebi.ac.uk/pdbsum/6lk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lk7 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Many root-colonizing Pseudomonas spp. exhibiting biocontrol activities produce a wide range of secondary metabolites that exert antibiotic effects against other microbes, nematodes, and insects in the rhizosphere. The expression of these secondary metabolites depends on the Gac/Rsm signal transduction pathway. Based on the findings of a previous genomic study on newly isolated biocontrol pseudomonad strains, we herein investigated the novel gene cluster OS3, which consists of four genes (Os1348-Os1351) that are located upstream of putative efflux transporter genes (Os1352-Os1355). Os1348 was predicted to encode an 85-aa small precursor protein, the expression of which was under the control of GacA, and an X-ray structural analysis suggested that the Os1348 protein formed a dimer. The mutational loss of the Os1348 gene decreased the antibiotic activity of Pseudomonas sp. Os17 without changing its growth rate. The Os1349-1351 genes were predicted to be involved in post-translational modifications. Intracellular levels of the Os1348 protein in the deficient mutant of each gene differed from that in wild-type cells. These results suggest that Os1348 is involved in antibiotic activity and that the structure or expression of this protein is under the control of downstream gene products.

 

== References ==

[[Category: Pseudomonas sp. os17]]

[[Category: Fujimoto, Z]]

[[Category: Someya, N]]

[[Category: Takeuchi, K]]

[[Category: Tsuchiya, W]]

[[Category: Yamada, K]]

[[Category: Yamazaki, T]]

[[Category: Unknown function]]