7b68

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Current revision (12:22, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7b68' size='340' side='right'caption='[[7b68]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
<StructureSection load='7b68' size='340' side='right'caption='[[7b68]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7b68]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B68 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7B68 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7b68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B68 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=LVV:4-[(4-methylphenyl)methyl]-1,4-thiazinane+1,1-dioxide'>LVV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate_ligase UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.13 6.3.2.13] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=LVV:4-[(4-methylphenyl)methyl]-1,4-thiazinane+1,1-dioxide'>LVV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7b68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b68 OCA], [http://pdbe.org/7b68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7b68 RCSB], [http://www.ebi.ac.uk/pdbsum/7b68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7b68 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b68 OCA], [https://pdbe.org/7b68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b68 RCSB], [https://www.ebi.ac.uk/pdbsum/7b68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b68 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI]] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref>
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[https://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref>
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==See Also==
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*[[Mur ligase|Mur ligase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Douangamath A]]
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[[Category: Delft, F von]]
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[[Category: Edwards AM]]
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[[Category: Douangamath, A]]
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[[Category: Fairhead M]]
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[[Category: Edwards, A M]]
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[[Category: Koekemoer L]]
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[[Category: Fairhead, M]]
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[[Category: Krojer T]]
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[[Category: Koekemoer, L]]
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[[Category: Steindel M]]
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[[Category: Krojer, T]]
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[[Category: Talon R]]
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[[Category: Structural genomic]]
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[[Category: Von Delft F]]
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[[Category: Steindel, M]]
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[[Category: Talon, R]]
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[[Category: 6-diaminopimelate ligase cell wall biosynthesis ligase drug target]]
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[[Category: Biosynthetic protein]]
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[[Category: Fragment screening]]
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[[Category: Sgc]]
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[[Category: Udp-n-acetylmuramoyl-l-alanyl-d-glutamate-2]]
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Current revision

Crystal structure of MurE from E.coli in complex with Z57299526

PDB ID 7b68

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