7b6i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:22, 1 February 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='7b6i' size='340' side='right'caption='[[7b6i]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='7b6i' size='340' side='right'caption='[[7b6i]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[7b6i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7B6I FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[7b6i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B6I FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SZE:4-(3-fluoranylpyridin-2-yl)-1-methyl-piperazin-2-one'>SZE</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.069&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate_ligase UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.13 6.3.2.13] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SZE:4-(3-fluoranylpyridin-2-yl)-1-methyl-piperazin-2-one'>SZE</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7b6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6i OCA], [http://pdbe.org/7b6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7b6i RCSB], [http://www.ebi.ac.uk/pdbsum/7b6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6i ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6i OCA], [https://pdbe.org/7b6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b6i RCSB], [https://www.ebi.ac.uk/pdbsum/7b6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI]] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref>
+
[https://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref>
 +
 
 +
==See Also==
 +
*[[Mur ligase|Mur ligase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Bountra C]]
-
[[Category: Bountra, C]]
+
[[Category: Douangamath A]]
-
[[Category: Delft, F von]]
+
[[Category: Edwards AM]]
-
[[Category: Douangamath, A]]
+
[[Category: Fairhead M]]
-
[[Category: Edwards, A M]]
+
[[Category: Koekemoer L]]
-
[[Category: Fairhead, M]]
+
[[Category: Krojer T]]
-
[[Category: Koekemoer, L]]
+
[[Category: Steindel M]]
-
[[Category: Krojer, T]]
+
[[Category: Talon R]]
-
[[Category: Structural genomic]]
+
[[Category: Von Delft F]]
-
[[Category: Steindel, M]]
+
-
[[Category: Talon, R]]
+
-
[[Category: 6-diaminopimelate ligase cell wall biosynthesis ligase drug target]]
+
-
[[Category: Biosynthetic protein]]
+
-
[[Category: Fragment screening]]
+
-
[[Category: Sgc]]
+
-
[[Category: Udp-n-acetylmuramoyl-l-alanyl-d-glutamate-2]]
+

Current revision

Crystal structure of MurE from E.coli in complex with Z1373445602

PDB ID 7b6i

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools