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1dfk

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{{STRUCTURE_1dfk| PDB=1dfk | SCENE= }}
{{STRUCTURE_1dfk| PDB=1dfk | SCENE= }}
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'''NUCLEOTIDE-FREE SCALLOP MYOSIN S1-NEAR RIGOR STATE'''
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===NUCLEOTIDE-FREE SCALLOP MYOSIN S1-NEAR RIGOR STATE===
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==Overview==
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We have determined the structure of the intact scallop myosin head, containing both the motor domain and the lever arm, in the nucleotide-free state and in the presence of MgADP.V04, corresponding to the transition state. These two new structures, together with the previously determined structure of scallop S1 complexed with MgADP (which we interpret as a detached ATP state), reveal three conformations of an intact S1 obtained from a single isoform. These studies, together with new crystallization results, show how the conformation of the motor depends on the nucleotide content of the active site. The resolution of the two new structures ( approximately 4 A) is sufficient to establish the relative positions of the subdomains and the overall conformation of the joints within the motor domain as well as the position of the lever arm. Comparison of available crystal structures from different myosin isoforms and truncated constructs in either the nucleotide-free or transition states indicates that the major features within the motor domain are relatively invariant in both these states. In contrast, the position of the lever arm varies significantly between different isoforms. These results indicate that the heavy-chain helix is pliant at the junction between the converter and the lever arm and that factors other than the precise position of the converter can influence the position of the lever arm. It is possible that this pliant junction in the myosin head contributes to the compliance known to be present in the crossbridge.
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The line below this paragraph, {{ABSTRACT_PUBMED_11016966}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11016966 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11016966}}
==About this Structure==
==About this Structure==
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[[Category: Conformational change]]
[[Category: Conformational change]]
[[Category: Myosin motor]]
[[Category: Myosin motor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:47:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:00:11 2008''

Revision as of 20:00, 30 June 2008

Image:1dfk.png

Template:STRUCTURE 1dfk

NUCLEOTIDE-FREE SCALLOP MYOSIN S1-NEAR RIGOR STATE

Template:ABSTRACT PUBMED 11016966

About this Structure

1DFK is a Protein complex structure of sequences from Argopecten irradians. Full crystallographic information is available from OCA.

Reference

Three conformational states of scallop myosin S1., Houdusse A, Szent-Gyorgyi AG, Cohen C, Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11238-43. PMID:11016966

Page seeded by OCA on Mon Jun 30 23:00:11 2008

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