6lo9

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Current revision (14:38, 29 November 2023) (edit) (undo)
 
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==Crystal structure of RORgammat with ligand C46D bound==
==Crystal structure of RORgammat with ligand C46D bound==
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<StructureSection load='6lo9' size='340' side='right'caption='[[6lo9]]' scene=''>
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<StructureSection load='6lo9' size='340' side='right'caption='[[6lo9]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LO9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LO9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6lo9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LO9 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lo9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lo9 OCA], [http://pdbe.org/6lo9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lo9 RCSB], [http://www.ebi.ac.uk/pdbsum/6lo9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lo9 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8600495&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ENU:6-cyclohexyloxy-9-ethyl-~{N}-[(4-ethylsulfonylphenyl)methyl]carbazole-3-carboxamide'>ENU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lo9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lo9 OCA], [https://pdbe.org/6lo9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lo9 RCSB], [https://www.ebi.ac.uk/pdbsum/6lo9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lo9 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Feng Y]]
[[Category: Feng Y]]
[[Category: Shijie C]]
[[Category: Shijie C]]

Current revision

Crystal structure of RORgammat with ligand C46D bound

PDB ID 6lo9

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