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1dg1

From Proteopedia

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{{STRUCTURE_1dg1| PDB=1dg1 | SCENE= }}
{{STRUCTURE_1dg1| PDB=1dg1 | SCENE= }}
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'''WHOLE, UNMODIFIED, EF-TU(ELONGATION FACTOR TU).'''
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===WHOLE, UNMODIFIED, EF-TU(ELONGATION FACTOR TU).===
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==Overview==
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BACKGROUND: The bacterial elongation factor EF-Tu recognizes and transports aminoacyl-tRNAs to mRNA-programmed ribosomes. EF-Tu shares many structural and functional properties with other GTPases whose conformations are regulated by guanine nucleotides. RESULTS: An intact form of Escherichia coli EF-Tu complexed with GDP has been crystallized in the presence of the EF-Tu-specific antibiotic GE2270 A. The three-dimensional structure has been solved by X-ray diffraction analysis and refined to a final crystallographic R factor of 17.2% at a resolution of 2.5 A. The location of the GE2270 A antibiotic-binding site could not be identified. CONCLUSIONS: The structure of EF-Tu-GDP is nearly identical to that of a trypsin-modified form of EF-Tu-GDP, demonstrating conclusively that the protease treatment had not altered any essential structural features. The present structure represents the first view of an ordered Switch I region in EF-Tu-GDP and reveals similarities with two other GTPases complexed with GDP: Ran and ADP-ribosylation factor-1. A comparison of the Switch I regions of the GTP and GDP forms of EF-Tu also reveals that a segment, six amino acids in length, completely converts from an alpha helix in the GTP complex to beta secondary structure in the GDP form. The alpha to beta switch in EF-Tu may represent a prototypical activation mechanism for other protein families.
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(as it appears on PubMed at http://www.pubmed.gov), where 8939740 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8939740}}
==About this Structure==
==About this Structure==
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[[Category: Trna binding]]
[[Category: Trna binding]]
[[Category: Ts binding protein]]
[[Category: Ts binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:48:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:01:36 2008''

Revision as of 20:01, 30 June 2008

Image:1dg1.png

Template:STRUCTURE 1dg1

WHOLE, UNMODIFIED, EF-TU(ELONGATION FACTOR TU).

Template:ABSTRACT PUBMED 8939740

About this Structure

1DG1 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

An alpha to beta conformational switch in EF-Tu., Abel K, Yoder MD, Hilgenfeld R, Jurnak F, Structure. 1996 Oct 15;4(10):1153-9. PMID:8939740

Page seeded by OCA on Mon Jun 30 23:01:36 2008

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