1wxp
From Proteopedia
(Difference between revisions)
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<StructureSection load='1wxp' size='340' side='right'caption='[[1wxp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='1wxp' size='340' side='right'caption='[[1wxp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1wxp]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1wxp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXP FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">THOC1 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">THOC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxp OCA], [https://pdbe.org/1wxp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxp RCSB], [https://www.ebi.ac.uk/pdbsum/1wxp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxp ProSAT], [https://www.topsan.org/Proteins/RSGI/1wxp TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/THOC1_HUMAN THOC1_HUMAN]] Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4.<ref>PMID:10512864</ref> <ref>PMID:10840029</ref> <ref>PMID:11050087</ref> <ref>PMID:11979277</ref> <ref>PMID:15833825</ref> <ref>PMID:15998806</ref> <ref>PMID:15870275</ref> <ref>PMID:17190602</ref> <ref>PMID:18974867</ref> Regulates transcriptional elongation of a subset of genes. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.<ref>PMID:10512864</ref> <ref>PMID:10840029</ref> <ref>PMID:11050087</ref> <ref>PMID:11979277</ref> <ref>PMID:15833825</ref> <ref>PMID:15998806</ref> <ref>PMID:15870275</ref> <ref>PMID:17190602</ref> <ref>PMID:18974867</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 07:01, 2 March 2022
Solution structure of the death domain of nuclear matrix protein p84
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