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1wyq

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<StructureSection load='1wyq' size='340' side='right'caption='[[1wyq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1wyq' size='340' side='right'caption='[[1wyq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WYQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WYQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WYQ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPTBN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPTBN2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wyq OCA], [http://pdbe.org/1wyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wyq RCSB], [http://www.ebi.ac.uk/pdbsum/1wyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wyq ProSAT], [http://www.topsan.org/Proteins/RSGI/1wyq TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wyq OCA], [https://pdbe.org/1wyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wyq RCSB], [https://www.ebi.ac.uk/pdbsum/1wyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wyq ProSAT], [https://www.topsan.org/Proteins/RSGI/1wyq TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/SPTN2_HUMAN SPTN2_HUMAN]] Defects in SPTBN2 are the cause of spinocerebellar ataxia type 5 (SCA5) [MIM:[http://omim.org/entry/600224 600224]]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA5 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder with variable age at onset, ranging between 10 and 50 years.<ref>PMID:16429157</ref>
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[[https://www.uniprot.org/uniprot/SPTN2_HUMAN SPTN2_HUMAN]] Defects in SPTBN2 are the cause of spinocerebellar ataxia type 5 (SCA5) [MIM:[https://omim.org/entry/600224 600224]]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA5 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder with variable age at onset, ranging between 10 and 50 years.<ref>PMID:16429157</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPTN2_HUMAN SPTN2_HUMAN]] Probably plays an important role in neuronal membrane skeleton.
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[[https://www.uniprot.org/uniprot/SPTN2_HUMAN SPTN2_HUMAN]] Probably plays an important role in neuronal membrane skeleton.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 07:01, 2 March 2022

Solution structure of the second CH domain of human spectrin beta chain, brain 2

PDB ID 1wyq

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