1x2q
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='1x2q' size='340' side='right'caption='[[1x2q]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='1x2q' size='340' side='right'caption='[[1x2q]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1x2q]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1x2q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X2Q FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STAM2 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STAM2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x2q OCA], [https://pdbe.org/1x2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x2q RCSB], [https://www.ebi.ac.uk/pdbsum/1x2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x2q ProSAT], [https://www.topsan.org/Proteins/RSGI/1x2q TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/STAM2_HUMAN STAM2_HUMAN]] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 07:02, 2 March 2022
Solution structure of the SH3 domain of the Signal transducing adaptor molecule 2
| |||||||||||
