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1x9n

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Current revision (14:03, 9 May 2024) (edit) (undo)
 
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<StructureSection load='1x9n' size='340' side='right'caption='[[1x9n]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='1x9n' size='340' side='right'caption='[[1x9n]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1x9n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X9N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1X9N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1x9n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X9N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LIG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x9n OCA], [https://pdbe.org/1x9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x9n RCSB], [https://www.ebi.ac.uk/pdbsum/1x9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x9n ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1x9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x9n OCA], [http://pdbe.org/1x9n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x9n RCSB], [http://www.ebi.ac.uk/pdbsum/1x9n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1x9n ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DNLI1_HUMAN DNLI1_HUMAN]] DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
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[https://www.uniprot.org/uniprot/DNLI1_HUMAN DNLI1_HUMAN] DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brien, P J.O]]
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[[Category: Ellenberger T]]
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[[Category: Ellenberger, T]]
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[[Category: O'Brien PJ]]
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[[Category: Pascal, J M]]
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[[Category: Pascal JM]]
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[[Category: Tomkinson, A E]]
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[[Category: Tomkinson AE]]
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[[Category: 5'-adenylated nicked dna]]
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[[Category: Dna ligase]]
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[[Category: Ligase-dna complex]]
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[[Category: Protein-dna complex]]
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Current revision

Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA

PDB ID 1x9n

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