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1xdx

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Revision as of 07:07, 2 March 2022

Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1

Structural highlights

1xdx is a 2 chain structure with sequence from Chlre. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	AF039437 (CHLRE)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Tctex1 is a light chain found in both cytoplasmic and flagellar dyneins and is involved in many fundamental cellular activities, including rhodopsin transport within photoreceptors, and may function in the non-Mendelian transmission of t haplotypes in mice. Here, we present the NMR solution structure for the Tctex1 dimer from Chlamydomonas axonemal inner dynein arm I1. Structural comparisons reveal a strong similarity with the LC8 dynein light chain dimer, including formation of a strand-switched beta sheet interface. Analysis of the Tctex1 structure enables the dynein intermediate chain binding site to be identified and suggests a mechanism by which cargo proteins might be attached to this microtubule motor complex. Comparison with the alternate dynein light chain rp3 reveals how the specificity of dynein-cargo interactions mediated by these dynein components is achieved. In addition, this structure provides insight into the consequences of the mutations found in the t haplotype forms of this protein.

Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions.,Wu H, Maciejewski MW, Takebe S, King SM Structure. 2005 Feb;13(2):213-23. PMID:15698565^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Wu H, Maciejewski MW, Takebe S, King SM. Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions. Structure. 2005 Feb;13(2):213-23. PMID:15698565 doi:10.1016/j.str.2004.11.013

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xdx"

@@ Line 3: / Line 3: @@
 <StructureSection load='1xdx' size='340' side='right'caption='[[1xdx]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1xdx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlre Chlre]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XDX FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1xdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlre Chlre]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XDX FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AF039437 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3055 CHLRE])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AF039437 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3055 CHLRE])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xdx OCA], [http://pdbe.org/1xdx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xdx RCSB], [http://www.ebi.ac.uk/pdbsum/1xdx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xdx ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xdx OCA], [https://pdbe.org/1xdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xdx RCSB], [https://www.ebi.ac.uk/pdbsum/1xdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xdx ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==

1xdx

From Proteopedia

Revision as of 07:07, 2 March 2022

Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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