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1dgn

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[[Image:1dgn.gif|left|200px]]
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[[Image:1dgn.png|left|200px]]
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{{STRUCTURE_1dgn| PDB=1dgn | SCENE= }}
{{STRUCTURE_1dgn| PDB=1dgn | SCENE= }}
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'''SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION'''
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===SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION===
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==Overview==
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ProIL-1beta is a proinflammatory cytokine that is proteolytically processed to its active form by caspase-1. Upon receipt of a proinflammatory stimulus, an upstream adaptor, RIP2, binds and oligomerizes caspase-1 zymogen, promoting its autoactivation. ICEBERG is a novel protein that inhibits generation of IL-1beta by interacting with caspase-1 and preventing its association with RIP2. ICEBERG is induced by proinflammatory stimuli, suggesting that it may be part of a negative feedback loop. Consistent with this, enforced retroviral expression of ICEBERG inhibits lipopolysaccharide-induced IL-1beta generation. The structure of ICEBERG reveals it to be a member of the death-domain-fold superfamily. The distribution of surface charge is complementary to the homologous prodomain of caspase-1, suggesting that charge-charge interactions mediate binding of ICEBERG to the prodomain of caspase-1.
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The line below this paragraph, {{ABSTRACT_PUBMED_11051551}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11051551 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11051551}}
==About this Structure==
==About this Structure==
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1DGN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGN OCA].
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1DGN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGN OCA].
==Reference==
==Reference==
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[[Category: Antiparallel six-helix bundle]]
[[Category: Antiparallel six-helix bundle]]
[[Category: Greek-key]]
[[Category: Greek-key]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:50:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:03:17 2008''

Revision as of 20:03, 30 June 2008

Image:1dgn.png

Template:STRUCTURE 1dgn

SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION

Template:ABSTRACT PUBMED 11051551

About this Structure

1DGN is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

ICEBERG: a novel inhibitor of interleukin-1beta generation., Humke EW, Shriver SK, Starovasnik MA, Fairbrother WJ, Dixit VM, Cell. 2000 Sep 29;103(1):99-111. PMID:11051551

Page seeded by OCA on Mon Jun 30 23:03:17 2008

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