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Undecaprenyl pyrophosphate synthase

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== Function ==
== Function ==
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'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transferase''' or '''poly-cys-prenyltransferase''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors.
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'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transfe rase''' or '''poly-cis-prenyltransferase''' or '''ditrans,polycis-undecaprenyl pyrophosphate synthase ((2E,6E) farnesyl diphosphate specific)''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors.
== Relevance ==
== Relevance ==
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**[[5xk3]] – StUPP – ''Streptmyces''<br />
**[[5xk3]] – StUPP – ''Streptmyces''<br />
**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br />
**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br />
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**[[6loi]] - AbUPP - ''Enterococcus faecalis''<br />
*Undecaprenyl pyrophosphate synthase complexes
*Undecaprenyl pyrophosphate synthase complexes

Revision as of 08:07, 7 January 2021

Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code 1x07).

Drag the structure with the mouse to rotate

3D structures of undecaprenyl pyrophosphate synthase

Updated on 07-January-2021

References

  1. ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
  2. ↑ Jukic M, Rozman K, Gobec S. Recent Advances in the Development of Undecaprenyl Pyrophosphate Synthase Inhibitors as Potential Antibacterials. Curr Med Chem. 2016;23(5):464-82. PMID:26718796
  3. ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200

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