Sandbox Reserved 1646

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== Disease ==
== Disease ==
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A mutation or a dysfonctionnement of the receptor could cause disease like idiopati hypogonadotropic hypogonadism (HH) which corresponds to a hypogonadism. <ref>DOI 10.1210/jc.2003-031808</ref>
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A mutation or a dysfonctionnement of the receptor could cause disease like idiopatic hypogonadotropic hypogonadism (HH) which is a disease causing hypogonadism. <ref DOI: 10.1016/j.cnur.2018.04.006</ref>.Indeed, in this case the mutation leads to failure of detectable ligand binding causing the decrease the efficiency of the inisitol pathway <ref>DOI 10.1210/jc.2003-031808</ref>.
== Relevance ==
== Relevance ==
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One of the main using of the couple GnRH - GnRHR in the medicine field is for fertility preservation <ref>DOI 10.1210/en.2013-1341</ref>. Indeed a mutation of the receptor gene sometimes lead to failure of detectable ligand binding
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One of the main using of the couple GnRH - GnRHR in the medicine field is for fertility preservation <ref>DOI 10.1210/en.2013-1341</ref>.
== Structural highlights ==
== Structural highlights ==

Revision as of 15:07, 8 January 2021

This Sandbox is Reserved from 26/11/2020, through 26/11/2021 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1643 through Sandbox Reserved 1664.
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Gonadotropin releasing hormone 1 receptor

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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E. Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary. Endocrinology. 2013 Oct;154(10):3877-87. doi: 10.1210/en.2013-1341. Epub 2013 Aug, 2. PMID:23913446 doi:http://dx.doi.org/10.1210/en.2013-1341
  4. ↑ .Indeed, in this case the mutation leads to failure of detectable ligand binding causing the decrease the efficiency of the inisitol pathway <ref>DOI 10.1210/jc.2003-031808</li> <li id="cite_note-4">[[#cite_ref-4|↑]] Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E. Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary. Endocrinology. 2013 Oct;154(10):3877-87. doi: 10.1210/en.2013-1341. Epub 2013 Aug, 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/23913446 23913446] doi:[http://dx.doi.org/10.1210/en.2013-1341 http://dx.doi.org/10.1210/en.2013-1341]</li></ol></ref>
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