Sandbox Reserved 1661
From Proteopedia
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| - | == | + | == Somatotropin and Genetic origin == |
| + | Somatotropin is a polypeptide hormone produced by the somatotropic cells of the pituitary gland. Growth hormone, a protein circulating in the blood. | ||
| + | The Human Growth Hormone has its origin on chromosome 17. There it gets encoded by the Growth hormone 1 gene along with four other related genes. Three of these genes are encoding human chorionic somatomammotropin, which is closely related to somatotropin. They are all in the same transcriptional orientation. | ||
| - | == | + | |
| + | == Functions == | ||
| + | Somatropin plays an important role in physiological environments such as: increasing muscle mass, reducing fat mass, providing the energy necessary for tissue growth, maintaining the right level of glucose and lipids ... and the development of the individual's body <ref> <ref name="ncbi> Southern Reh, C. and E Geffner, M. (2010), Somatotropin in the treatment of growth hormone defiviency and Tuuner syndrome in pediatric patients: a review. Clin Pharmacol. 2010; 2:11-112. doi: 10.2147/CPAA.S6525. <ref>PMID:22291494</ref> DOI 10.2147/CPAA.S6525</ref> . It acts directly on a cell surface or indirectly <ref name="ncbi" />. In the second case, somatropin stimulates tissues such as the liver, which in turn allows the synthesis and secretion of IGF-1, thus enabling the development of cell growth, tissue, bone and thus the linear growth of the individual <ref> <ref name="britannica"> Utiger, R. D. and other Encyclopedia Britannica Contributors (1998), Insulin-like growth factor. Science, Chemistry.</ref>. | ||
== Relevance == | == Relevance == | ||
Revision as of 19:49, 13 January 2021
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| This Sandbox is Reserved from 26/11/2020, through 26/11/2021 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1643 through Sandbox Reserved 1664. |
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ <ref> Southern Reh, C. and E Geffner, M. (2010), Somatotropin in the treatment of growth hormone defiviency and Tuuner syndrome in pediatric patients: a review. Clin Pharmacol. 2010; 2:11-112. doi: 10.2147/CPAA.S6525. <ref>PMID:22291494</li> <li id="cite_note-ncbi">[[#cite_ref-ncbi_0|↑]] <strong class="error">Cite error: Invalid <code><ref></code> tag; no text was provided for refs named <code>ncbi</code></strong></li> <li id="cite_note-4">[[#cite_ref-4|↑]] <ref name="britannica"> Utiger, R. D. and other Encyclopedia Britannica Contributors (1998), Insulin-like growth factor. Science, Chemistry.</li></ol></ref>
