1di0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1di0.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1di0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1di0| PDB=1di0 | SCENE= }}
{{STRUCTURE_1di0| PDB=1di0 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF LUMAZINE SYNTHASE FROM BRUCELLA ABORTUS'''
+
===CRYSTAL STRUCTURE OF LUMAZINE SYNTHASE FROM BRUCELLA ABORTUS===
-
==Overview==
+
<!--
-
We have determined the three-dimensional structure of 6, 7-dimethyl-8-ribityllumazine synthase (lumazine synthase) from Brucella abortus, the infectious organism of the disease brucellosis in animals. This enzyme catalyses the formation of 6, 7-dimethyl-8-ribityllumazine, the penultimate product in the synthesis of riboflavin. The three-dimensional X-ray crystal structure of the enzyme from B. abortus has been solved and refined at 2.7 A resolution to a final R-value of 0.18 (R(free)=0.23). The macromolecular assembly of the enzyme differs from that of the enzyme from Bacillus subtilis, the only other lumazine synthase structure known. While the protein from B. subtilis assembles into a 60 subunit icosahedral capsid built from 12 pentameric units, the enzyme from B. abortus is pentameric in its crystalline form. Nonetheless, the active sites of the two enzymes are virtually identical indicating inhibitors to theses enzymes could be effective pharmaceuticals across a broad species range. Furthermore, we compare the structures of the enzyme from B. subtilis and B. abortus and describe the C teminus structure which accounts for the differences in quaternary structure.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10764570}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10764570 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10764570}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Velikovsky, C A.]]
[[Category: Velikovsky, C A.]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:51:52 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:05:21 2008''

Revision as of 20:05, 30 June 2008

Image:1di0.png

Template:STRUCTURE 1di0

CRYSTAL STRUCTURE OF LUMAZINE SYNTHASE FROM BRUCELLA ABORTUS

Template:ABSTRACT PUBMED 10764570

About this Structure

1DI0 is a Single protein structure of sequence from Brucella abortus. Full crystallographic information is available from OCA.

Reference

Divergence in macromolecular assembly: X-ray crystallographic structure analysis of lumazine synthase from Brucella abortus., Braden BC, Velikovsky CA, Cauerhff AA, Polikarpov I, Goldbaum FA, J Mol Biol. 2000 Apr 14;297(5):1031-6. PMID:10764570

Page seeded by OCA on Mon Jun 30 23:05:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1di0"
Personal tools