Sandbox Reserved 1662
From Proteopedia
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UCP2 is 309 amino acids long with domains located in the mitochondrial matrix, in the inner mitochondrial membrane and in the intermembrane mitochondrial space. | UCP2 is 309 amino acids long with domains located in the mitochondrial matrix, in the inner mitochondrial membrane and in the intermembrane mitochondrial space. | ||
| - | More precisely it can be described as a chain of six transmembrane helices and three amphipathic helices. The structure consists of three pseudo-repeats in which a transmembrane helix is linked by a loop to an amphipathic helix, followed by another transmembrane alpha helix. <ref> Kream, E., Mitochondrial uncoupling protein 2 [https://collab.its.virginia.edu/access/content/group/f85bed6c-45d2-4b18-b868-6a2353586804/2/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)-_-/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)_MitochondrialUncouplingProtein2.html] <ref/> | + | More precisely it can be described as a chain of six transmembrane helices and three amphipathic helices. The structure consists of three pseudo-repeats in which a transmembrane helix is linked by a loop to an amphipathic helix, followed by another transmembrane alpha helix.<ref>Kream, E., Mitochondrial uncoupling protein 2 [https://collab.its.virginia.edu/access/content/group/f85bed6c-45d2-4b18-b868-6a2353586804/2/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)-_-/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)_MitochondrialUncouplingProtein2.html]<ref/> |
In addition, transmembrane helices are mainly composed of Hydrophobic amino acids with a lot of alanine, valine and leucine. <ref>[https://www.uniprot.org/uniprot/P70406] UniProtKB - P70406 UCP2_MOUSE <ref/> | In addition, transmembrane helices are mainly composed of Hydrophobic amino acids with a lot of alanine, valine and leucine. <ref>[https://www.uniprot.org/uniprot/P70406] UniProtKB - P70406 UCP2_MOUSE <ref/> | ||
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<references/> | <references/> | ||
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| - | <ref>Ricquier, D., Bouillaud, F., (2000) The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220743/pdf/10620491.pdf]<ref/> | ||
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| - | <ref>Chomiki, N., Voss, J.C., Warden, C.H., (2001) Structure-fonction relationships in UCP1, UCP2 and chimeras[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220743/pdf/10620491.pdf]<ref/> | ||
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| - | <ref>Kream, E., Mitochondrial uncoupling protein 2 [https://collab.its.virginia.edu/access/content/group/f85bed6c-45d2-4b18-b868-6a2353586804/2/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)-_-/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)_MitochondrialUncouplingProtein2.html]<ref/> | ||
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| - | <ref>[https://www.uniprot.org/uniprot/P70406] UniProtKB - P70406 UCP2_MOUSE <ref/> | ||
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| - | <ref>Berardi, M.J., Shih, M.W., Harrison, S.C., Chou, J.J., Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching[https://doi.org/10.1038/nature10257]<ref/> | ||
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| - | <ref>Hoang, T., Matovic, T., Parker, J., Smith, M.D., Jelokhani-Niaraki, M., Role of Positively Charged Residues of the Second Transmembrane Domain in the Ion Transport Activity and Conformation of Human Uncoupling Protein-2, Biochemistry 2015, 54, 14, 2303–2313, [https://doi.org/10.1021/acs.biochem.5b00177]<ref/> | ||
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UCP2
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The UCP2 protein is a transmembrane protein found in mitochondrias in different tissues such as white adipose and muscular tissues. This protein allows an uncoupling of the electrochemical potential of membrane in the respiratory chain of mitochondria resulting in a heat creation. This protein is a carrier of protons and chlorides.
A transmembrane protein
UCP2 is 309 amino acids long with domains located in the mitochondrial matrix, in the inner mitochondrial membrane and in the intermembrane mitochondrial space. More precisely it can be described as a chain of six transmembrane helices and three amphipathic helices. The structure consists of three pseudo-repeats in which a transmembrane helix is linked by a loop to an amphipathic helix, followed by another transmembrane alpha helix.[1]
