1djm

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[[Image:1djm.jpg|left|200px]]
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{{Seed}}
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[[Image:1djm.png|left|200px]]
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{{STRUCTURE_1djm| PDB=1djm | SCENE= }}
{{STRUCTURE_1djm| PDB=1djm | SCENE= }}
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'''SOLUTION STRUCTURE OF BEF3-ACTIVATED CHEY FROM ESCHERICHIA COLI'''
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===SOLUTION STRUCTURE OF BEF3-ACTIVATED CHEY FROM ESCHERICHIA COLI===
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==Overview==
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The CheY protein is the response regulator in bacterial chemotaxis. Phosphorylation of a conserved aspartyl residue induces structural changes that convert the protein from an inactive to an active state. The short half-life of the aspartyl-phosphate has precluded detailed structural analysis of the active protein. Persistent activation of Escherichia coli CheY was achieved by complexation with beryllofluoride (BeF(3)(-)) and the structure determined by NMR spectroscopy to a backbone r.m.s.d. of 0.58(+/-0.08) A. Formation of a hydrogen bond between the Thr87 OH group and an active site acceptor, presumably Asp57.BeF(3)(-), stabilizes a coupled rearrangement of highly conserved residues, Thr87 and Tyr106, along with displacement of beta4 and H4, to yield the active state. The coupled rearrangement may be a more general mechanism for activation of receiver domains.
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The line below this paragraph, {{ABSTRACT_PUBMED_10731410}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10731410 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10731410}}
==About this Structure==
==About this Structure==
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1DJM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DJM OCA].
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1DJM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DJM OCA].
==Reference==
==Reference==
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[[Category: Response regulator]]
[[Category: Response regulator]]
[[Category: Two-component]]
[[Category: Two-component]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:55:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:09:56 2008''

Revision as of 20:09, 30 June 2008

Image:1djm.png

Template:STRUCTURE 1djm

SOLUTION STRUCTURE OF BEF3-ACTIVATED CHEY FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 10731410

About this Structure

1DJM is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

NMR structure of activated CheY., Cho HS, Lee SY, Yan D, Pan X, Parkinson JS, Kustu S, Wemmer DE, Pelton JG, J Mol Biol. 2000 Mar 31;297(3):543-51. PMID:10731410

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