1z56

<table><tr><td colspan='2'>[[1z56]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z56 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Z56 FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LIF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), DNL4, LIG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1z56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z56 OCA], [http://pdbe.org/1z56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z56 RCSB], [http://www.ebi.ac.uk/pdbsum/1z56 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z56 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/DNLI4_YEAST DNLI4_YEAST]] Has minor DNA joining activity. Can act on oligo(PDT)/poly(rA) substrate. [[http://www.uniprot.org/uniprot/LIF1_YEAST LIF1_YEAST]] Stabilizes DNL4. Involved in non-homologous repair of DNA double-strand breaks.<ref>PMID:9670033</ref>

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== Publication Abstract from PubMed ==

DNA ligase IV catalyses the final ligation step in the non-homologous end-joining (NHEJ) DNA repair pathway and requires interaction of the ligase with the Xrcc4 'genome-guardian', an essential NHEJ factor. Here we report the 3.9 A crystal structure of the Saccharomyces cerevisiae Xrcc4 ortholog ligase interacting factor 1 (Lif1p) complexed with the C-terminal BRCT domains of DNA ligase IV (Lig4p). The structure reveals a novel mode of protein recognition by a tandem BRCT repeat, and in addition provides a molecular basis for a human LIG4 syndrome clinical condition.

Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.,Dore AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL DNA Repair (Amst). 2006 Mar 7;5(3):362-8. Epub 2006 Jan 18. PMID:16388993<ref>PMID:16388993</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1z56" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Atcc 18824]]

[[Category: Blundell, T L]]

[[Category: Chirgadze, D Y]]

[[Category: Davies, O R]]

[[Category: Dore, A S]]

[[Category: Furnham, N]]

[[Category: Jackson, S P]]

[[Category: Pellegrini, L]]

[[Category: Sibanda, B L]]

[[Category: Xrcc4]]