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1dl6

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[[Image:1dl6.gif|left|200px]]
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{{Seed}}
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[[Image:1dl6.png|left|200px]]
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{{STRUCTURE_1dl6| PDB=1dl6 | SCENE= }}
{{STRUCTURE_1dl6| PDB=1dl6 | SCENE= }}
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'''SOLUTION STRUCTURE OF HUMAN TFIIB N-TERMINAL DOMAIN'''
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===SOLUTION STRUCTURE OF HUMAN TFIIB N-TERMINAL DOMAIN===
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==Overview==
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Transcription factor IIB (TFIIB) is an essential component in the formation of the transcription initiation complex in eucaryal and archaeal transcription. TFIIB interacts with a promoter complex containing the TATA-binding protein (TBP) to facilitate interaction with RNA polymerase II (RNA pol II) and the associated transcription factor IIF (TFIIF). TFIIB contains a zinc-binding motif near the N-terminus that is directly involved in the interaction with RNA pol II/TFIIF and plays a crucial role in selecting the transcription initiation site. The solution structure of the N-terminal residues 2-59 of human TFIIB was determined by multidimensional NMR spectroscopy. The structure consists of a nearly tetrahedral Zn(Cys)3(His)1 site confined by type I and "rubredoxin" turns, three antiparallel beta-strands, and disordered loops. The structure is similar to the reported zinc-ribbon motifs in several transcription-related proteins from archaea and eucarya, including Pyrococcus furiosus transcription factor B (PfTFB), human and yeast transcription factor IIS (TFIIS), and Thermococcus celer RNA polymerase II subunit M (TcRPOM). The zinc-ribbon structure of TFIIB, in conjunction with the biochemical analyses, suggests that residues on the beta-sheet are involved in the interaction with RNA pol II/TFIIF, while the zinc-binding site may increase the stability of the beta-sheet.
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The line below this paragraph, {{ABSTRACT_PUBMED_11045620}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11045620 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11045620}}
==About this Structure==
==About this Structure==
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1DL6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DL6 OCA].
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1DL6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DL6 OCA].
==Reference==
==Reference==
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[[Category: Scott, R A.]]
[[Category: Scott, R A.]]
[[Category: Zinc ribbon]]
[[Category: Zinc ribbon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:58:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:14:13 2008''

Revision as of 20:14, 30 June 2008

Image:1dl6.png

Template:STRUCTURE 1dl6

SOLUTION STRUCTURE OF HUMAN TFIIB N-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 11045620

About this Structure

1DL6 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription., Chen HT, Legault P, Glushka J, Omichinski JG, Scott RA, Protein Sci. 2000 Sep;9(9):1743-52. PMID:11045620

Page seeded by OCA on Mon Jun 30 23:14:13 2008

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