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1zrh
From Proteopedia
(Difference between revisions)
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<StructureSection load='1zrh' size='340' side='right'caption='[[1zrh]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='1zrh' size='340' side='right'caption='[[1zrh]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1zrh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1zrh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZRH FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zrh OCA], [https://pdbe.org/1zrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zrh RCSB], [https://www.ebi.ac.uk/pdbsum/1zrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zrh ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zrh OCA], [https://pdbe.org/1zrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zrh RCSB], [https://www.ebi.ac.uk/pdbsum/1zrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zrh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/HS3S1_HUMAN HS3S1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.<ref>PMID:9346953</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Sulfotransferase|Sulfotransferase]] | + | *[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Bochkarev A]] |
| - | [[Category: Dombrovski | + | [[Category: Dombrovski L]] |
| - | [[Category: Dong | + | [[Category: Dong A]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Loppnau | + | [[Category: Loppnau P]] |
| - | [[Category: Plotnikov | + | [[Category: Plotnikov AN]] |
| - | + | [[Category: Sundstrom M]] | |
| - | [[Category: Sundstrom | + | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP
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