2a3q
From Proteopedia
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<StructureSection load='2a3q' size='340' side='right'caption='[[2a3q]], [[Resolution|resolution]] 2.32Å' scene=''> | <StructureSection load='2a3q' size='340' side='right'caption='[[2a3q]], [[Resolution|resolution]] 2.32Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2a3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2a3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A3Q FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3q OCA], [https://pdbe.org/2a3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a3q RCSB], [https://www.ebi.ac.uk/pdbsum/2a3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a3q ProSAT], [https://www.topsan.org/Proteins/CESG/2a3q TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3q OCA], [https://pdbe.org/2a3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a3q RCSB], [https://www.ebi.ac.uk/pdbsum/2a3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a3q ProSAT], [https://www.topsan.org/Proteins/CESG/2a3q TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DCTP1_MOUSE DCTP1_MOUSE] Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases.<ref>PMID:17320107</ref> <ref>PMID:19220460</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a3q ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a3q ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Allard | + | [[Category: Allard STM]] |
| - | [[Category: Bingman | + | [[Category: Bingman CA]] |
| - | [[Category: Bitto | + | [[Category: Bitto E]] |
| - | + | [[Category: Mccoy JG]] | |
| - | [[Category: Mccoy | + | [[Category: Phillips Jr GN]] |
| - | [[Category: Phillips | + | [[Category: Wesenberg GE]] |
| - | [[Category: Wesenberg | + | |
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Revision as of 08:15, 15 May 2024
X-Ray Structure of Protein from Mus Musculus MM.29898
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