2an1

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Current revision (09:13, 14 February 2024) (edit) (undo)
 
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<StructureSection load='2an1' size='340' side='right'caption='[[2an1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2an1' size='340' side='right'caption='[[2an1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2an1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AN1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2an1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AN1 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yfjB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_kinase NAD(+) kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.23 2.7.1.23] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2an1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2an1 OCA], [https://pdbe.org/2an1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2an1 RCSB], [https://www.ebi.ac.uk/pdbsum/2an1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2an1 ProSAT], [https://www.topsan.org/Proteins/MCSG/2an1 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2an1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2an1 OCA], [https://pdbe.org/2an1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2an1 RCSB], [https://www.ebi.ac.uk/pdbsum/2an1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2an1 ProSAT], [https://www.topsan.org/Proteins/MCSG/2an1 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NADK_SALTY NADK_SALTY]] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates as a source of phosphorus. NADH can not replace NAD as a substrate.[HAMAP-Rule:MF_00361]<ref>PMID:16682646</ref>
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[https://www.uniprot.org/uniprot/NADK_SALTY NADK_SALTY] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates as a source of phosphorus. NADH can not replace NAD as a substrate.[HAMAP-Rule:MF_00361]<ref>PMID:16682646</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Salty]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Collart, F]]
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[[Category: Collart F]]
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[[Category: Holzle, D]]
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[[Category: Holzle D]]
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[[Category: Joachimiak, A]]
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[[Category: Joachimiak A]]
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[[Category: Structural genomic]]
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[[Category: Zhang R]]
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[[Category: Zhang, R]]
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[[Category: Zhou M]]
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[[Category: Zhou, M]]
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[[Category: Mcsg]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Putative kinase]]
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[[Category: Transferase]]
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Current revision

Structural Genomics, The crystal structure of a putative kinase from Salmonella typhimurim LT2

PDB ID 2an1

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