2aow

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Current revision (07:27, 23 August 2023) (edit) (undo)
 
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<StructureSection load='2aow' size='340' side='right'caption='[[2aow]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
<StructureSection load='2aow' size='340' side='right'caption='[[2aow]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2aow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AOW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2aow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AOW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=THA:TACRINE'>THA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jqd|1jqd]], [[1jqe|1jqe]], [[2aot|2aot]], [[2aou|2aou]], [[2aov|2aov]], [[2aox|2aox]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=THA:TACRINE'>THA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HNMT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Histamine_N-methyltransferase Histamine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.8 2.1.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aow OCA], [https://pdbe.org/2aow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aow RCSB], [https://www.ebi.ac.uk/pdbsum/2aow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aow ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aow OCA], [https://pdbe.org/2aow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aow RCSB], [https://www.ebi.ac.uk/pdbsum/2aow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aow ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HNMT_HUMAN HNMT_HUMAN]] Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
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[https://www.uniprot.org/uniprot/HNMT_HUMAN HNMT_HUMAN] Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Histamine N-methyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cheng, X]]
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[[Category: Cheng X]]
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[[Category: Horton, J R]]
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[[Category: Horton JR]]
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[[Category: Nishibori, M]]
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[[Category: Nishibori M]]
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[[Category: Sawada, K]]
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[[Category: Sawada K]]
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[[Category: Classic methyltransferase fold]]
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[[Category: Protein-drug complex]]
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[[Category: Transferase]]
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Current revision

Histamine Methyltransferase (Natural Variant I105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine

PDB ID 2aow

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