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2aqb

From Proteopedia

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Current revision (07:28, 23 August 2023) (edit) (undo)
 
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<StructureSection load='2aqb' size='340' side='right'caption='[[2aqb]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='2aqb' size='340' side='right'caption='[[2aqb]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2aqb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AQB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2aqb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AQB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TL6:(5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE'>TL6</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fj4|1fj4]], [[2aq7|2aq7]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TL6:(5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE'>TL6</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fabB, fabC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aqb OCA], [https://pdbe.org/2aqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aqb RCSB], [https://www.ebi.ac.uk/pdbsum/2aqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aqb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aqb OCA], [https://pdbe.org/2aqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aqb RCSB], [https://www.ebi.ac.uk/pdbsum/2aqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aqb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.
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[https://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Boshoff, H I]]
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[[Category: Boshoff HI]]
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[[Category: Goodwin, M B]]
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[[Category: Goodwin MB]]
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[[Category: Kim, P]]
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[[Category: Kim P]]
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[[Category: Lonsdale, J]]
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[[Category: Lonsdale J]]
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[[Category: Manjunatha, U H]]
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[[Category: Manjunatha UH]]
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[[Category: Miller, D J]]
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[[Category: Miller DJ]]
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[[Category: Nguyen, Q A]]
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[[Category: Nguyen QA]]
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[[Category: Price, A C]]
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[[Category: Price AC]]
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[[Category: Shenoy, G]]
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[[Category: Shenoy G]]
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[[Category: Zhang, Y M]]
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[[Category: Zhang YM]]
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[[Category: Fabb-ligand active-site complex]]
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[[Category: Transferase]]
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Current revision

Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli

PDB ID 2aqb

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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