1dlz

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{{Seed}}
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{{STRUCTURE_1dlz| PDB=1dlz | SCENE= }}
{{STRUCTURE_1dlz| PDB=1dlz | SCENE= }}
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'''SOLUTION STRUCTURE OF THE CHANNEL-FORMER ZERVAMICIN IIB (PEPTAIBOL ANTIBIOTIC)'''
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===SOLUTION STRUCTURE OF THE CHANNEL-FORMER ZERVAMICIN IIB (PEPTAIBOL ANTIBIOTIC)===
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==Overview==
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Spatial structure of the membrane channel-forming hexadecapeptide, zervamicin IIB, was studied by NMR spectroscopy in mixed solvents of different polarity ranging from CDCl3/CD3OH (9:1, v/v) to CD3OH/H2O (1:1, v/v). The results show that in all solvents used the peptide has a very similar structure that is a bent amphiphilic helix with a mean backbone root mean square deviation (rmsd) value of ca. 0.3 A. Side chains of Trp1, Ile2, Gln3, Ile5 and Thr6 are mobile. The results are discussed in relation to the validity of the obtained structure to serve as a building block of zervamicin IIB ion channels.
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The line below this paragraph, {{ABSTRACT_PUBMED_10682854}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10682854 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10682854}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLZ OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLZ OCA].
==Reference==
==Reference==
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[[Category: Peptaibol]]
[[Category: Peptaibol]]
[[Category: Zervamicin]]
[[Category: Zervamicin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:00:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:16:24 2008''

Revision as of 20:16, 30 June 2008

Image:1dlz.png

Template:STRUCTURE 1dlz

SOLUTION STRUCTURE OF THE CHANNEL-FORMER ZERVAMICIN IIB (PEPTAIBOL ANTIBIOTIC)

Template:ABSTRACT PUBMED 10682854

About this Structure

Full experimental information is available from OCA.

Reference

NMR structure of the channel-former zervamicin IIB in isotropic solvents., Balashova TA, Shenkarev ZO, Tagaev AA, Ovchinnikova TV, Raap J, Arseniev AS, FEBS Lett. 2000 Jan 28;466(2-3):333-6. PMID:10682854

Page seeded by OCA on Mon Jun 30 23:16:24 2008

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