Replication protein E1

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(New page: <StructureSection load='2ayg' size='340' side='right' caption='Human papillomavirus 6a regulatory protein E2 complex with DNA (PDB code 2ayg)' scene=''> ==Function== '''Replication p...)
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<StructureSection load='2ayg' size='340' side='right' caption='Human papillomavirus 6a regulatory protein E2 complex with DNA (PDB code [[2ayg]])' scene=''>
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<StructureSection load='2gxa' size='340' side='right' caption='Bovine papillomavirus 1 replication protein E1 complex with DNA (PDB code [[2gxa]])' scene=''>
==Function==
==Function==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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Domains: transactivation (TAD) 2-201; DNA-binding (DBD) 286-365
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Domains: helicase 301-605; DNA-binding (DBD) 286-365
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[[1r8h]], [[2aye]] - RPE2 DBD - HPV6a<br />
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[[1r9w]] - RPE1 DBD - HPV18<br />
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[[2ayb]], [[2ayg]] - RPE2 DBD + DNA<br />
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[[1tue]] - RPE1 428-631 (mutant) + RPE2 TAD<br />
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[[1r6k]], [[1r6n]] - RPE2 TAD + inhibitor - HPV11<br />
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[[2v9p]] - RPE1 helicase domain - BPV1<br />
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[[1dto]] - RPE2 TAD - HPV16<br />
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[[5a9k]] - RPE1 helicase domain - Cryo EM<br />
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[[2nnu]] - RPE2 TAD + BRD4 peptide<br />
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[[2gxa]] - RPE1 helicase domain + DNA + ADP<br />
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[[1by9]], [[2q79]] - RPE2 DBD<br />
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[[1f08]] - RPE1 DBD<br />
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[[3mi7]] - RPE2 DBD (mutant)<br />
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[[1ksx]], [[1ksy]] - RPE1 DBD + DNA<br />
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[[1r8p]], [[1zzf]] - RPE2 DBD - NMR<br />
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[[1tue]] - RPE1 428-631 (mutant) + RPE2 TAD - HPV18<br />
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[[1qqh]] - RPE2 TAD<br />
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[[1f9f]] - RPE2 DBD<br />
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[[1jj4]] - RPE2 DBD + DNA<br />
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[[1dhm]] - RPE2 DBD - HPV31 - NMR<br />
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[[1a7g]] - RPE2 DBD - HPV32<br />
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[[2jeu]], [[2jex]] - RPE2 TAD (mutant) - BPV1<br />
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[[1jjh]], [[6bus]] - RPE2 DBD<br />
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[[1dbd]] - RPE2 DBD - NMR<br />
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[[2bop]] - RPE2 DBD + DNA<br />
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== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:37, 27 January 2021

Bovine papillomavirus 1 replication protein E1 complex with DNA (PDB code 2gxa)

Drag the structure with the mouse to rotate

3D structures of regulatory protein E2

Updated on 27-January-2021

Domains: helicase 301-605; DNA-binding (DBD) 286-365

1r9w - RPE1 DBD - HPV18
1tue - RPE1 428-631 (mutant) + RPE2 TAD
2v9p - RPE1 helicase domain - BPV1
5a9k - RPE1 helicase domain - Cryo EM
2gxa - RPE1 helicase domain + DNA + ADP
1f08 - RPE1 DBD
1ksx, 1ksy - RPE1 DBD + DNA

References

  1. ↑ Wilson VG, West M, Woytek K, Rangasamy D. Papillomavirus E1 proteins: form, function, and features. Virus Genes. 2002 Jun;24(3):275-90. doi: 10.1023/a:1015336817836. PMID:12086149 doi:http://dx.doi.org/10.1023/a:1015336817836
  2. ↑ Singh N, Senapati S, Bose K. Insights into the mechanism of human papillomavirus E2-induced procaspase-8 activation and cell death. Sci Rep. 2016 Feb 24;6:21408. doi: 10.1038/srep21408. PMID:26906543 doi:http://dx.doi.org/10.1038/srep21408
  3. ↑ Hooley E, Fairweather V, Clarke AR, Gaston K, Brady RL. The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein. Nucleic Acids Res. 2006;34(14):3897-908. Epub 2006 Aug 12. PMID:16914454 doi:10.1093/nar/gkl466

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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