UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

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Revision as of 07:39, 28 January 2021

E. coli UDP-N-acetylglucosamine acyltransferase complex with UDP-Glc-NAC (PDB code 2jf3)

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Updated on 28-January-2021

↑ Bainbridge BW, Karimi-Naser L, Reife R, Blethen F, Ernst RK, Darveau RP. Acyl chain specificity of the acyltransferases LpxA and LpxD and substrate availability contribute to lipid A fatty acid heterogeneity in Porphyromonas gingivalis. J Bacteriol. 2008 Jul;190(13):4549-58. doi: 10.1128/JB.00234-08. Epub 2008 May 2. PMID:18456814 doi:http://dx.doi.org/10.1128/JB.00234-08
↑ Jenkins RJ, Dotson GD. Dual targeting antibacterial peptide inhibitor of early lipid A biosynthesis. ACS Chem Biol. 2012 Jul 20;7(7):1170-7. doi: 10.1021/cb300094a. Epub 2012 Apr 27. PMID:22530734 doi:http://dx.doi.org/10.1021/cb300094a
↑ Ulaganathan V, Buetow L, Hunter WN. Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis. J Mol Biol. 2007 Jun 1;369(2):305-12. Epub 2007 Mar 21. PMID:17434525 doi:10.1016/j.jmb.2007.03.039

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 == Function ==
 '''UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase'''
-'''UDP-N-acetylglucosamine acyltransferase''' or
+(LpxD) is involved in the biosynthesis of lipid A which is a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.  Thus, LpxD is essential to survival of Gram-negative bacteria.  It catalyzes the N-acylation of UDP-3-O-(3-hydroxytetradeanoyl)glucosamine<ref>PMID:18456814</ref>.
-'''Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase''' (LpxD) initiates lipid A biosynthesis.  It catalyzes the transfer of 3-hydroxymyristic acid from acyl carrier protein to the 3'-hydroxyl group of UDP-GlcNAc<ref>PMID:10480918</ref>.
+== Relevance ==
+LpxD inhibitors are antimicrobials<ref>PMID:22530734</ref>.
 == Structural highlights ==