Ubiquitin activating enzyme

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== 3D Structures of ubiquitin activating enzyme ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Ubiquitin activating enzyme E1
 
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**[[4p22]] – hUba N-terminal (mutant) - human<BR />
 
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**[[4ii2]] – hUba + E2 Ubc4 + ubiquitin-ribosomal protein L40 + ATP<BR />
 
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**[[4ii3]] – hUba + ubiquitin-ribosomal protein L40 + ATP <BR />
 
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**[[6dc6]] – hUba (mutant) + ubiquitin <BR />
 
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**[[6nya]] – hUba1 + Ubc3 + ubiquitin <BR />
 
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**[[1z7l]] – mUba 1 second catalytic Cys half-domain - mouse <BR />
 
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**[[2v31]] – mUba X first catalytic Cys half-domain <BR />
 
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**[[2lzj]] – mUba X first catalytic Cys half-domain - NMR <BR />
 
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**[[5um6]] – fyUba1 – fission yeast <BR />
 
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**[[6o83]], [[6o82]] – fyUba + ubiquitin-ribosomal protein L40 + adenosine derivative <BR />
 
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**[[5um6]] – yUba (mutant) – yeast <BR />
 
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**[[3cmm]], [[4nnj]] – yUba + ubiquitin + AMP <BR />
 
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**[[5tr4]] – yUba (mutant) + ubiquitin <BR />
 
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**[[6zqh]] – yUba + ubiquitin-ribosomal protein S31<BR />
 
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**[[5l6h]], [[5l6i]], [[5l6j]] – yUba + ubiquitin-ribosomal protein S31 + inhibitor <BR />
 
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**[[5knl]] – yUba + ubiquitin + E2 <BR />
 
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*Ubiquitin activating enzyme E1-like
 
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**[[3ong]], [[3onh]] – yUba + SUMO-conjugating enzyme Ubc9 <BR />
 
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*Ubiquitin activating enzyme E1C or NEDD8-activating enzyme ubiquitin activating enzyme 3 subunit
 
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**[[2lq7]] – hUba catlytic subunit - NMR <BR />
 
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**[[1r4m]] – hUba + NEDD8 <BR />
 
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**[[1r4n]] – hUba (mutant) + NEDD8 + APPBP1 + ATP <BR />
 
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**[[1tt5]] – hUba + E2 Ubc12 + APPBP1 <BR />
 
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**[[1y8x]] – hUba + E2 Ubc12 <BR />
 
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**[[1yov]] – hUba + APPBP1 <BR />
 
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**[[3dbr]] – hUba + APPBP1 (mutant) + NEDD8 <BR />
 
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**[[2nvu]] – hUba + E2 Ubc12 + APPBP1 + NEDD8 + ATP <BR />
 
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**[[3gzn]] – hUba + inhibitor + APPBP1 + NEDD8 + ATP <BR />
 
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**[[3dbh]], [[3dbl]] – hUba (mutant) + NEDD8 <BR />
 
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**[[3fn1]] – hUba (mutant) + NEDD8-conjugating enzyme <BR />
 
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*Ubiquitin activating enzyme 5 or Ubiquitin-like modifier-activating enzyme 5
 
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**[[5ia8]] – hUba residues 1-83 <BR />
 
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**[[3guc]] – hUba + AMPPNP <BR />
 
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**[[3h8v]], [[6h78]] – hUba + ATP <BR />
 
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**[[5iaa]] – hUba + UFM1 <BR />
 
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**[[5l95]] – hUba + UFM1 + AMP<BR />
 
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**[[6h77]] – hUba + UFM1 + ATP<BR />
 
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* Ubiquitin-like 1 activating enzyme E1A or SUMO-1 activating enzyme subunit 1
 
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**[[1y8r]] – hSAE subunit 1 + hSAE subunit 2 + SMTC3 <BR />
 
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* Ubiquitin-like modifier-activating enzyme 2 or SUMO-activating enzyme subunit 2
 
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**[[6cwz]] – hSAE subunits 1,2<BR />
 
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**[[6cwy]] – hSAE subunits 1,2 + inhibitor<BR />
 
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**[[3kyc]] – hSAE subunits 1,2 + SUMO <BR />
 
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**[[3kyd]] – hSAE subunits 1,2 + SUMO + AMP <BR />
 
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**[[5fq2]], [[4w5v]] – hSAE ubiquitin domain + Ubc9 <BR />
 
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* Ubiquitin-like modifier-activating enzyme 5
 
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**[[6h78]] – hSAE + ATP<BR />
 
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**[[6h77]] – hSAE + ubiquitin-fold modifier + ATP<BR />
 
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**[[6h8c]] – hSAE LIR motif + GABARAPL2 - NMR<BR />
 
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* Ubiquitin-like modifier-activating enzyme Atg7 see [[Autophagy-related protein]]
 
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==References==
==References==
<references />
<references />
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:26, 3 February 2021

Structure of human ubiquitin activating enzyme Uba3 subunit (green) complex with E2 Ubc12 (cyan) (PDB entry 1y8x)

Drag the structure with the mouse to rotate

References

  1. Nagai Y, Kaneda S, Nomura K, Yasuda H, Seno T, Yamao F. Ubiquitin-activating enzyme, E1, is phosphorylated in mammalian cells by the protein kinase Cdc2. J Cell Sci. 1995 Jun;108 ( Pt 6):2145-52. PMID:7673335

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Michal Harel, Alexander Berchansky

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