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1dmg

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{{STRUCTURE_1dmg| PDB=1dmg | SCENE= }}
{{STRUCTURE_1dmg| PDB=1dmg | SCENE= }}
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'''CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN L4'''
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===CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN L4===
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==Overview==
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Ribosomal protein L4 resides near the peptidyl transferase center of the bacterial ribosome and may, together with rRNA and proteins L2 and L3, actively participate in the catalysis of peptide bond formation. Escherichia coli L4 is also an autogenous feedback regulator of transcription and translation of the 11 gene S10 operon. The crystal structure of L4 from Thermotoga maritima at 1.7 A resolution shows the protein with an alternating alpha/beta fold and a large disordered loop region. Two separate binding sites for RNA are discernible. The N-terminal site, responsible for binding to rRNA, consists of the disordered loop with flanking alpha-helices. The C-terminal site, a prime candidate for the interaction with the leader sequence of the S10 mRNA, involves two non-consecutive alpha-helices. The structure also suggests a C-terminal protein-binding interface, through which L4 could be interacting with protein components of the transcriptional and/or translational machineries.
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(as it appears on PubMed at http://www.pubmed.gov), where 10698923 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10698923}}
==About this Structure==
==About this Structure==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: S10 operon]]
[[Category: S10 operon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:01:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:17:44 2008''

Revision as of 20:17, 30 June 2008

Image:1dmg.png

Template:STRUCTURE 1dmg

CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN L4

Template:ABSTRACT PUBMED 10698923

About this Structure

1DMG is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon., Worbs M, Huber R, Wahl MC, EMBO J. 2000 Mar 1;19(5):807-18. PMID:10698923

Page seeded by OCA on Mon Jun 30 23:17:44 2008

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