7kao

==Cryo-EM structure of the Sec complex from S. cerevisiae, Sec61 pore mutant, class without Sec62==

<StructureSection load='7kao' size='340' side='right'caption='[[7kao]], [[Resolution|resolution]] 4.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[7kao]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KAO FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kao OCA], [https://pdbe.org/7kao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kao RCSB], [https://www.ebi.ac.uk/pdbsum/7kao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kao ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/SEC66_YEAST SEC66_YEAST] Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC66 is required to attach or retain SEC72 in the SEC63 complex. It is essential for growth at elevated temperatures.

[[Category: Saccharomyces cerevisiae S288C]]

[[Category: Park E]]