2b6m
From Proteopedia
(Difference between revisions)
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<StructureSection load='2b6m' size='340' side='right'caption='[[2b6m]], [[Resolution|resolution]] 2.65Å' scene=''> | <StructureSection load='2b6m' size='340' side='right'caption='[[2b6m]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2b6m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2b6m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B6M FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | <tr id=' | + | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b6m OCA], [https://pdbe.org/2b6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b6m RCSB], [https://www.ebi.ac.uk/pdbsum/2b6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b6m ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b6m OCA], [https://pdbe.org/2b6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b6m RCSB], [https://www.ebi.ac.uk/pdbsum/2b6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b6m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Royant | + | [[Category: Royant A]] |
| - | [[Category: Serre | + | [[Category: Serre L]] |
| - | [[Category: Vives | + | [[Category: Vives C]] |
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Revision as of 06:23, 3 April 2024
Structure of the DsbA mutant (P31A-C33A)
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