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2d9n

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Current revision (11:36, 22 May 2024) (edit) (undo)
 
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==Solution structure of CCCH type zinc-finger domain 2 in Cleavage and polyadenylation specificity factor==
==Solution structure of CCCH type zinc-finger domain 2 in Cleavage and polyadenylation specificity factor==
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<StructureSection load='2d9n' size='340' side='right'caption='[[2d9n]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2d9n' size='340' side='right'caption='[[2d9n]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2d9n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D9N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2d9n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D9N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CPSF4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9n OCA], [https://pdbe.org/2d9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9n RCSB], [https://www.ebi.ac.uk/pdbsum/2d9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9n ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9n TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9n OCA], [https://pdbe.org/2d9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9n RCSB], [https://www.ebi.ac.uk/pdbsum/2d9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9n ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9n TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CPSF4_HUMAN CPSF4_HUMAN]] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).<ref>PMID:9224719</ref> <ref>PMID:14749727</ref>
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[https://www.uniprot.org/uniprot/CPSF4_HUMAN CPSF4_HUMAN] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).<ref>PMID:9224719</ref> <ref>PMID:14749727</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abe, C]]
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[[Category: Abe C]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y]]
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[[Category: Muto Y]]
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[[Category: Structural genomic]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M]]
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[[Category: Terada T]]
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[[Category: Terada, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Ccch zinc-finger]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rna binding protein]]
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[[Category: Rsgi]]
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Current revision

Solution structure of CCCH type zinc-finger domain 2 in Cleavage and polyadenylation specificity factor

PDB ID 2d9n

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