2daq
From Proteopedia
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==Solution structure of second PWWP domain of WHSC1L1 protein== | ==Solution structure of second PWWP domain of WHSC1L1 protein== | ||
| - | <StructureSection load='2daq' size='340' side='right'caption='[[2daq | + | <StructureSection load='2daq' size='340' side='right'caption='[[2daq]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2daq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2daq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DAQ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2daq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2daq OCA], [https://pdbe.org/2daq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2daq RCSB], [https://www.ebi.ac.uk/pdbsum/2daq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2daq ProSAT], [https://www.topsan.org/Proteins/RSGI/2daq TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2daq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2daq OCA], [https://pdbe.org/2daq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2daq RCSB], [https://www.ebi.ac.uk/pdbsum/2daq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2daq ProSAT], [https://www.topsan.org/Proteins/RSGI/2daq TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | [[Category: Niraula | + | [[Category: Niraula TN]] |
| - | + | [[Category: Tochio N]] | |
| - | [[Category: Tochio | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of second PWWP domain of WHSC1L1 protein
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Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Niraula TN | Tochio N | Yokoyama S
