2dlr
From Proteopedia
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==Solution structure of the RGS domain of human Regulator of G-protein signaling 10== | ==Solution structure of the RGS domain of human Regulator of G-protein signaling 10== | ||
| - | <StructureSection load='2dlr' size='340' side='right'caption='[[2dlr | + | <StructureSection load='2dlr' size='340' side='right'caption='[[2dlr]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2dlr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2dlr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DLR FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dlr OCA], [https://pdbe.org/2dlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dlr RCSB], [https://www.ebi.ac.uk/pdbsum/2dlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dlr ProSAT], [https://www.topsan.org/Proteins/RSGI/2dlr TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dlr OCA], [https://pdbe.org/2dlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dlr RCSB], [https://www.ebi.ac.uk/pdbsum/2dlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dlr ProSAT], [https://www.topsan.org/Proteins/RSGI/2dlr TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/RGS10_HUMAN RGS10_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Hayashi | + | [[Category: Hayashi F]] |
| - | [[Category: Nagashima | + | [[Category: Nagashima T]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Yokoyama | + | [[Category: Zhang HP]] |
| - | [[Category: Zhang | + | |
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Current revision
Solution structure of the RGS domain of human Regulator of G-protein signaling 10
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