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1dnv

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{{STRUCTURE_1dnv| PDB=1dnv | SCENE= }}
{{STRUCTURE_1dnv| PDB=1dnv | SCENE= }}
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'''PARVOVIRUS (DENSOVIRUS) FROM GALLERIA MELLONELLA'''
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===PARVOVIRUS (DENSOVIRUS) FROM GALLERIA MELLONELLA===
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==Overview==
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BACKGROUND: Parvoviruses infect vertebrates, insects and crustaceans. Many arthropod parvoviruses (densoviruses) are highly pathogenic and kill approximately 90% of the host larvae within days, making them potentially effective as selective pesticides. Improved understanding of densoviral structure and function is therefore desirable. There are four different initiation sites for translation of the densovirus capsid protein mRNA, giving rise to the viral proteins VP1 to VP4. Sixty copies of the common, C-terminal domain make up the ordered part of the icosahedral capsid. RESULTS: The Galleria mellonella densovirus (GMDNV) capsid protein consists of a core beta-barrel motif, similar to that found in many other viral capsid proteins. The structure most closely resembles that of the vertebrate parvoviruses, but it has diverged beyond recognition in many of the long loop regions that constitute the surface features and intersubunit contacts. The N termini of twofold-related subunits have swapped their positions relative to those of the vertebrate parvoviruses. Unlike in the vertebrate parvoviruses, in GmDNV there is no continuous electron density in the channels running along the fivefold axes of the virus. Electron density corresponding to some of the single-stranded DNA genome is visible in the crystal structure, but it is not as well defined as in the vertebrate parvoviruses. CONCLUSIONS: The sequence of the glycine-rich motif, which occupies each of the channels along the fivefold axes in vertebrate viruses, is conserved between mammalian and insect parvoviruses. This motif may serve to externalize the N-terminal region of the single VP1 subunit per particle. The domain swapping of the N termini between insect and vertebrate parvoviruses may have the effect of increasing capsid stability in GmDNV.
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(as it appears on PubMed at http://www.pubmed.gov), where 9817847 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9817847}}
==About this Structure==
==About this Structure==
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[[Category: Parvovirus]]
[[Category: Parvovirus]]
[[Category: Viral capsid]]
[[Category: Viral capsid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:03:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:20:58 2008''

Revision as of 20:21, 30 June 2008

Image:1dnv.png

Template:STRUCTURE 1dnv

PARVOVIRUS (DENSOVIRUS) FROM GALLERIA MELLONELLA

Template:ABSTRACT PUBMED 9817847

About this Structure

1DNV is a Single protein structure of sequence from Galleria mellonella densovirus. Full crystallographic information is available from OCA.

Reference

The structure of an insect parvovirus (Galleria mellonella densovirus) at 3.7 A resolution., Simpson AA, Chipman PR, Baker TS, Tijssen P, Rossmann MG, Structure. 1998 Nov 15;6(11):1355-67. PMID:9817847

Page seeded by OCA on Mon Jun 30 23:20:58 2008

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