This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Buried charges detection

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
<span class="text-red">This page is under development. [[User:Eric Martz|Eric Martz]] 20:04, 8 February 2021 (UTC)</span>
<span class="text-red">This page is under development. [[User:Eric Martz|Eric Martz]] 20:04, 8 February 2021 (UTC)</span>
-
The four amino acids whose sidechains are fully charged from pH 5 to 9, in the absence of environmental effects, are Arg, Asp, Glu, Lys<ref name="pace">PMID: 19164280</ref>. Although these sidechains tend to be on the surfaces of soluble proteins, they are often found buried in the hydrophobic cores<ref name="pace" />. In fact, on average, about half of Arg, Asp, and Glu sidechains are buried, while about one third of Lys sidechains are buried<ref name="pace" />.
+
The four amino acids whose sidechains are fully charged from pH 5 to 9, in the absence of environmental effects, are Arg, Asp, Glu, Lys<ref name="pace">PMID: 19164280</ref>. Although the highly hydrophilic sidechains of these amino acids tend to be on the surfaces of soluble proteins, they are often found buried in the hydrophobic cores<ref name="pace" />. In fact, on average, about half of Arg, Asp, and Glu sidechains are buried, while about one third of Lys sidechains are buried<ref name="pace" />.
==Notes to myself==
==Notes to myself==

Revision as of 23:06, 8 February 2021

This page is under development. Eric Martz 20:04, 8 February 2021 (UTC)

The four amino acids whose sidechains are fully charged from pH 5 to 9, in the absence of environmental effects, are Arg, Asp, Glu, Lys[1]. Although the highly hydrophilic sidechains of these amino acids tend to be on the surfaces of soluble proteins, they are often found buried in the hydrophobic cores[1]. In fact, on average, about half of Arg, Asp, and Glu sidechains are buried, while about one third of Lys sidechains are buried[1].

Notes to myself

Burial 1990, awaiting interlibrary[2]

References Cited

  1. ↑ 1.0 1.1 1.2 Pace CN, Grimsley GR, Scholtz JM. Protein ionizable groups: pK values and their contribution to protein stability and solubility. J Biol Chem. 2009 May 15;284(20):13285-9. doi: 10.1074/jbc.R800080200. Epub 2009 , Jan 21. PMID:19164280 doi:http://dx.doi.org/10.1074/jbc.R800080200
  2. ↑ Lesser GJ, Rose GD. Hydrophobicity of amino acid subgroups in proteins. Proteins. 1990;8(1):6-13. doi: 10.1002/prot.340080104. PMID:2217164 doi:http://dx.doi.org/10.1002/prot.340080104

Proteopedia Page Contributors and Editors (what is this?)

Eric Martz

Retrieved from "http://52.214.119.220/wiki/index.php/Buried_charges_detection"
Personal tools