1doi

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{{STRUCTURE_1doi| PDB=1doi | SCENE= }}
{{STRUCTURE_1doi| PDB=1doi | SCENE= }}
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'''2FE-2S FERREDOXIN FROM HALOARCULA MARISMORTUI'''
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===2FE-2S FERREDOXIN FROM HALOARCULA MARISMORTUI===
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==Overview==
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Haloarcula marismortui is an archaebacterium that flourishes in the world's saltiest body of water, the Dead Sea. The cytosol of this organism is a supersaturated salt solution in which proteins are soluble and active. The crystal structure of a 2Fe-2S ferredoxin from H. marismortui determined at 1.9 A is similar to those of plant-type 2Fe-2S ferredoxins of known structure, with two important distinctions. The entire surface of the protein is coated with acidic residues except for the vicinity of the iron-sulphur cluster, and there is an insertion of two amphipathic helices near the N-terminus. These form a separate hyperacidic domain whose postulated function to provide extra surface carboxylates for solvation. These data and the fact that bound surface water molecules have on the average 40% more hydrogen bonds than in a typical non-halophilic protein crystal structure support the notion that haloadaptation involves better water binding capacity.
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The line below this paragraph, {{ABSTRACT_PUBMED_8612076}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8612076 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8612076}}
==About this Structure==
==About this Structure==
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[[Category: Iron-sulfur]]
[[Category: Iron-sulfur]]
[[Category: Redox protein]]
[[Category: Redox protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:05:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:22:47 2008''

Revision as of 20:22, 30 June 2008

Image:1doi.png

Template:STRUCTURE 1doi

2FE-2S FERREDOXIN FROM HALOARCULA MARISMORTUI

Template:ABSTRACT PUBMED 8612076

About this Structure

1DOI is a Single protein structure of sequence from Haloarcula marismortui. Full crystallographic information is available from OCA.

Reference

Insights into protein adaptation to a saturated salt environment from the crystal structure of a halophilic 2Fe-2S ferredoxin., Frolow F, Harel M, Sussman JL, Mevarech M, Shoham M, Nat Struct Biol. 1996 May;3(5):452-8. PMID:8612076

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