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2dn9
From Proteopedia
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==Solution structure of J-domain from the DnaJ homolog, human Tid1 protein== | ==Solution structure of J-domain from the DnaJ homolog, human Tid1 protein== | ||
| - | <StructureSection load='2dn9' size='340' side='right'caption='[[2dn9 | + | <StructureSection load='2dn9' size='340' side='right'caption='[[2dn9]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2dn9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2dn9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DN9 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dn9 OCA], [https://pdbe.org/2dn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dn9 RCSB], [https://www.ebi.ac.uk/pdbsum/2dn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dn9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dn9 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dn9 OCA], [https://pdbe.org/2dn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dn9 RCSB], [https://www.ebi.ac.uk/pdbsum/2dn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dn9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dn9 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DNJA3_HUMAN DNJA3_HUMAN] Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Kobayashi | + | [[Category: Kobayashi N]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | + | [[Category: Tomizawa T]] | |
| - | [[Category: Tomizawa | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of J-domain from the DnaJ homolog, human Tid1 protein
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