This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2e1o
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution structure of RSGI RUH-028, a homeobox domain from human cDNA== | ==Solution structure of RSGI RUH-028, a homeobox domain from human cDNA== | ||
| - | <StructureSection load='2e1o' size='340' side='right'caption='[[2e1o | + | <StructureSection load='2e1o' size='340' side='right'caption='[[2e1o]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2e1o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2e1o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wqi 1wqi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E1O FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e1o OCA], [https://pdbe.org/2e1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e1o RCSB], [https://www.ebi.ac.uk/pdbsum/2e1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e1o ProSAT], [https://www.topsan.org/Proteins/RSGI/2e1o TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e1o OCA], [https://pdbe.org/2e1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e1o RCSB], [https://www.ebi.ac.uk/pdbsum/2e1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e1o ProSAT], [https://www.topsan.org/Proteins/RSGI/2e1o TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/HHEX_HUMAN HHEX_HUMAN] Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 21: | Line 21: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Abe | + | [[Category: Abe T]] |
| - | [[Category: Hirota | + | [[Category: Hirota H]] |
| - | [[Category: Kawaii | + | [[Category: Kawaii S]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | [[Category: Nakamura | + | [[Category: Nakamura A]] |
| - | [[Category: Nameki | + | [[Category: Nameki N]] |
| - | [[Category: Ohnishi | + | [[Category: Ohnishi S]] |
| - | + | [[Category: Tochio N]] | |
| - | [[Category: Tochio | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution structure of RSGI RUH-028, a homeobox domain from human cDNA
| |||||||||||
Categories: Homo sapiens | Large Structures | Abe T | Hirota H | Kawaii S | Kigawa T | Koshiba S | Nakamura A | Nameki N | Ohnishi S | Tochio N | Yokoyama S
