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2e42
From Proteopedia
(Difference between revisions)
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<StructureSection load='2e42' size='340' side='right'caption='[[2e42]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2e42' size='340' side='right'caption='[[2e42]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2e42]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2e42]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E42 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e42 OCA], [https://pdbe.org/2e42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e42 RCSB], [https://www.ebi.ac.uk/pdbsum/2e42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e42 ProSAT], [https://www.topsan.org/Proteins/RSGI/2e42 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e42 OCA], [https://pdbe.org/2e42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e42 RCSB], [https://www.ebi.ac.uk/pdbsum/2e42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e42 ProSAT], [https://www.topsan.org/Proteins/RSGI/2e42 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:20829347</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Hamada | + | [[Category: Hamada K]] |
| - | [[Category: Inoue-Bungo | + | [[Category: Inoue-Bungo T]] |
| - | [[Category: Ogata | + | [[Category: Ogata K]] |
| - | [[Category: Sato | + | [[Category: Sato K]] |
| - | [[Category: Shiina | + | [[Category: Shiina M]] |
| - | [[Category: Tahirov | + | [[Category: Tahirov TH]] |
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Current revision
Crystal structure of C/EBPbeta Bzip homodimer V285A mutant bound to A High Affinity DNA fragment
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Categories: Homo sapiens | Large Structures | Hamada K | Inoue-Bungo T | Ogata K | Sato K | Shiina M | Tahirov TH
